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Amoxicillin capsule storage condition after 3 days of storage at 1 °C (0 - 8 °C). The capsules were dried in a drying oven by an increase of 100% for 15 minutes (OBSK) and were then stored at 4 °C. The remaining 50 mg of active medication was stored at room temperature a 1 : 2 concentration. The capsules were stored in a cool place. The capsules were kept refrigerated and used within 2 days after their expiration date. Table 1. Pharmacokinetic parameters after a single dose of 10-20 mg/kg orally administered imipenem sodium plus ampicillin. The following parameters are expressed in nanograms per milliliter (ng/mL): i) Maximum plasma concentration. For the analysis of pharmacokinetics this compound, the concentration in plasma was measured after three separate dosing sessions: (i) after 24 h (N + = 3); (ii) at the time when plasma concentration was equal to or below the minimum inhibitory concentration (MIC; N + = 3); and (iii) at the time when MIC was equal to or below the maximum therapeutic concentration (Ci(iT), N + = 3). (ii) Plasma concentrations of imipenem and ampicillin are expressed relative to the lower limit of detection (LOD). A. The mean plasma concentrations after treatment with imipenem and ampicillin for a three day period are shown. Data expressed as nanograms per milliliter (ng/mL). *=p < 0.001, **= p ***= ****= < 0.001. Table 2. Pharmacokinetics after 10, 20 and 50 mg/kg oral administration of imipenem sodium plus ampicillin in 14 subjects. The following parameters are expressed in nM: i) Maximum plasma concentration. For the analysis of pharmacokinetics this compound, the concentration in plasma was measured after seven separate dosing sessions: (i) before dosing; (ii) during dosing (N + = 3); (iii) 15 min afterwards (N + = 3); (iv) after 4 h (N + maxalt generic dosage = 3); (v) after 8 h (N + = 3); (vi) after 12 h (N + = 3); (vii) after 16 h (N + = 3); (viii) after 21 h (N + = 3). c. The following pharmacokinetic parameters were calculated using the specific activities of imipenem and ampicillin per milliliter (ng/mL): i) Specific activity of ampicillin (iT = 4) in a 14-subject study. The following specific activities, measured by LC-MS (in nmol/LC-MS/MS) after single doses, are shown for ampicillin (AMPMI) amoxicillin (AMPV), and for imipenem sodium generic medicine for maxalt (IMAPC): ampicillin AMPMI = 1.07 mg/mL; AMPV 0.57 ampicillin IMAPC = 0.03 mg/mL. A, Pharmacokinetics evaluation of a single dose imipenem (10-14 mg/kg) plus ampicillin in a 13 subjects aged 35 to 55 years. The pharmacokinetics were evaluated at concentrations noted in Table 3. Data are expressed as nM: i) time to reach the maximum plasma concentration; (ii) time to reach the lowest concentration; (iii) time to reach the maximum therapeutic concentration (Ci(iT)); (iv) time to reach the lowest concentration (Ci(iT)). *=p < 0.05, **=p 0.01, ***=p 0.001, ****=p < 0.001. (B) In a 24 h test, the pharmacokinetics were evaluated in a group of 15 subjects aged 39 to 52 years, after oral administration of imipenem and ampicillin (N = 15). The time to reach maximum plasma concentration was 7.5 h during imipenem (+imipenem), 6.5 ampicillin (−amy.
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